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Shanghai Korain Biotech Co Ltd
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Thermo Fisher
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Genzyme
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Novus Biologicals
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Sanofi
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Genzyme
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Cusabio
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Journal: Leukemia & lymphoma
Article Title: Soluble CD52 is an indicator of disease activity in chronic lymphocytic leukemia.
doi: 10.1080/10428194.2017.1285027
Figure Lengend Snippet: Figure 1. Levels of sCD52 quantified by ELISA. (A) healthy blood donors (n ¼ 45) and patients with CLL (n ¼ 86). (B) patients with early CLL (n ¼ 44) and with progressive CLL (progressive CLL, n ¼ 42). (C) patients with early CLL and progressive CLL by Binet stage grading A (n ¼ 39 and n ¼ 6, early CLL and progressive CLL, respectively), vs. B/C (n ¼ 4 and n ¼ 36, early CLL and progres- sive CLL, respectively). (D) Levels of sCD52 and b2-microglobulin (b2m) in patients with early CLL (n ¼ 26) and progressive CLL (n ¼ 30). Statistical analyses were performed as unpaired Student’s t tests and linear regression analysis, data were logarithmically transformed.
Article Snippet: sCD52 was quantified in plasma or serum by a commercial
Techniques: Enzyme-linked Immunosorbent Assay, Transformation Assay
Journal: Leukemia & lymphoma
Article Title: Soluble CD52 is an indicator of disease activity in chronic lymphocytic leukemia.
doi: 10.1080/10428194.2017.1285027
Figure Lengend Snippet: Figure 2. Levels of sCD52 and time to first treatment (TTFT) in ‘early’ CLL. (A) TTFT in patients with ‘early’ CLL divided by the median sCD52 level (n ¼ 44). (B) TTFT in patients with ‘early’ CLL at diagnosis based on sCD52 and IGHV mutational status, a sub- group of the patients shown in A (n ¼ 34). Statistical analyses were performed as log rank test, cumulative incidence rates are shown. M-IGHV: mutated IGHV, UM-IGHV: unmutated IGHV. The median level of sCD52 (274 ng/mL) in ‘early CLL’ patients with a sCD52 level above lower limit of quantification in the ELISA found to discriminate best between healthy donors and patients with CLL by ROC curve analysis, data not shown.
Article Snippet: sCD52 was quantified in plasma or serum by a commercial
Techniques: Biomarker Discovery, Enzyme-linked Immunosorbent Assay